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Citation-first clinical tool
Metformin Renal Dose Adjustment Lookup
Metformin is contraindicated below an eGFR of 30; reduced dosing is considered between 30 and 45 per FDA labelling.
This tool is for educational and decision-support use only. It does not replace independent clinical judgement. Always verify against the current guideline, FDA label, or specialty reference cited below before acting. Do not enter patient identifiers (name, MRN, dates of service).
Tool
FDA Drug Label + KDIGO + Sanford Guide
(2024)
— FDA / KDIGO / Sanford
— read source
Primary publication: Each response names the specific FDA label and KDIGO publication.
Who this is for
- Hospitalists and APPs prescribing renally / hepatically cleared agents
- Internal medicine and nephrology trainees
- Inpatient and community pharmacists
Frequently asked questions
Does the tool replace the FDA label?
No. It surfaces the label structure for fast review; the clinician should always confirm against the current FDA label before prescribing.
Are dialysis-specific doses included?
Yes when the FDA label or KDIGO provides them. Intermittent vs continuous dialysis often differ; verify with your renal pharmacist.
Is Child-Pugh always applicable?
No. Many drugs have only renal-elimination data and no hepatic-impairment guidance. The tool will note when hepatic data is unavailable.
Can I look up multiple drugs at once?
One drug per request to keep output focused. For polypharmacy, run several lookups or escalate to clinical pharmacy.
What if the FDA label is silent?
The tool will surface that gap, point to alternative references (Sanford, KDIGO, Aronoff), and recommend pharmacy review.