Citation-first clinical tool

AI Drug Interaction Checker (Cited)

The Rounds Drug Interaction Checker takes a list of medications and returns a structured interaction summary for each pair: severity band (contraindicated / major / moderate / minor / not commonly clinically significant), mechanism, clinical effect, monitoring considerations, and the FDA label or commercial reference (Lexicomp, Micromedex) to verify. The tool surfaces the most important pairs for clinician review; severity classifications and monitoring conventions should be confirmed against your institutional pharmacy reference.

This tool is for educational and decision-support use only. It does not replace independent clinical judgement. Always verify against the current guideline, FDA label, or specialty reference cited below before acting. Do not enter patient identifiers (name, MRN, dates of service).

FDA Drug-Drug Interaction Labeling Guidance (2020) — U.S. FDA — read source Primary publication: Lexicomp / Micromedex commercial DDI databases

Who this is for

Hospitalists, primary care clinicians, and APPs reconciling polypharmacy
Pharmacists performing prescribing reviews
Medical students learning pharmacokinetics and pharmacodynamics

Frequently asked questions

Is this a substitute for Lexicomp or Micromedex?

No. It is a fast first-pass review. Final clinical decisions should be confirmed against an authoritative DDI database your institution has licensed.

How many medications can I check at once?

The tool accepts up to 15 medications per request to keep responses readable. Larger reconciliations should be done in chunks or with a pharmacist.

Will it cover supplement interactions?

Yes when well-documented (St John's wort, grapefruit, vitamin K antagonists). For less-studied supplements, the tool flags uncertainty.

Are pharmacokinetic and pharmacodynamic interactions both surfaced?

Yes — mechanism is included so clinicians can distinguish CYP-mediated, transporter-mediated, and additive pharmacodynamic interactions (QT, serotonin, bleeding).

Does the severity band determine action?

It supports prioritisation. 'Contraindicated' typically prompts deprescribing; 'major' typically prompts monitoring or alternative agent; 'moderate / minor' commonly informs surveillance. Verify per institutional convention.

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Frequently asked questions

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