Sublingual Amfexa (Immediate-Release Dextroamphetamine) Duration of Action
Published clinical pharmacology sources do not provide dosing-route-specific evidence showing a change in the duration of action of Amfexa (immediate-release dextroamphetamine) when given sublingually versus standard oral immediate-release dosing.
For standard oral immediate-release dextroamphetamine, the duration of action is approximately 4 to 6 hours, with a time to peak plasma concentration (Tmax) of about 3 hours. [1]
Key Clinical Comparison: Oral Immediate-Release Reference Duration
- Oral immediate-release dextroamphetamine duration of action: ~4–6 hours. [1]
- Oral immediate-release dextroamphetamine Tmax: ~3 hours. [1]
Evidence Gap for Sublingual Administration
- No authoritative, route-specific pharmacokinetic or pharmacodynamic data were located that quantify duration-of-effect after sublingual Amfexa compared with oral immediate-release dosing. (Inference based on absence of route-specific evidence in the retrieved pharmacology references.) [1]