Tirzepatide Systemic Clearance and Organ Impairment Dose Adjustments
Tirzepatide has an apparent population mean clearance of 0.061 L/h. [1] Renal or hepatic impairment does not require tirzepatide dose adjustment. [1], [2]
Systemic Clearance
Tirzepatide clearance is reported as an apparent population mean clearance of 0.061 L/h. [1]
Renal Impairment Dose Adjustment Requirements
Renal impairment, including end-stage renal disease (ESRD), is reported to show no change in tirzepatide pharmacokinetics, and no dose adjustment is required. [1], [2]
Hepatic Impairment Dose Adjustment Requirements
Hepatic impairment is reported to show no change in tirzepatide pharmacokinetics, and no dose adjustment is required. [1], [2]
Pharmacokinetic Implication for Clinical Dosing
Because renal and hepatic impairment do not change tirzepatide pharmacokinetics, dosing adjustments based solely on renal function category or hepatic impairment category are not recommended. [1], [2]