Mannitol-Associated Pulmonary Edema
Mannitol can cause pulmonary edema, particularly when renal function is impaired or when excess intravascular volume or osmotically active fluid accumulates. [1]
Clinical Mechanisms
Mannitol has the potential to contribute to pulmonary edema through osmotic effects and impaired clearance, which can lead to fluid shifts and volume overload in susceptible patients. [1]
Risk Factors
Mannitol-associated pulmonary edema is reported in settings of compromised renal function. [1]
Dose- and Context-Related Considerations
Pulmonary edema has been reported despite aggressive supportive care when mannitol therapy occurs in patients with impaired ability to clear the drug. [1]
Recognition and Management
Pulmonary edema associated with mannitol should prompt immediate reassessment of ongoing mannitol use and consideration of supportive measures for respiratory failure and volume management. [1]
Common Pitfalls to Avoid
Continued mannitol administration without close monitoring of renal function and clinical volume status in patients at risk for impaired clearance can be associated with severe complications, including intractable pulmonary edema. [1]