Pistachio Intake and Serum Uric Acid Levels
High-quality direct evidence evaluating pistachio consumption and its effect on serum uric acid is not available.
General controlled-feeding evidence indicates that fructose does not increase serum uric acid when fructose is provided under isocaloric conditions, although hypercaloric fructose intake can increase serum uric acid. [1]
Evidence Base From Related Dietary Carbohydrate
A systematic review and meta-analysis of controlled dietary trials found no significant increase in serum uric acid with isocaloric replacement of fructose for other carbohydrate. [1]
The same analysis found that hypercaloric fructose supplementation increased serum uric acid compared with control diets, with results consistent with a role of excess energy rather than fructose alone. [1]