Opioid MME (Morphine Milligram Equivalent) Calculator
Morphine milligram equivalents (MME) is a standardised conversion framework used to summate daily opioid burden across multiple agents. The CDC 2022 Clinical Practice Guideline for Prescribing Opioids retained MME as a tool for clinical safety review while explicitly cautioning against its use as a hard prescribing threshold. This calculator implements the CDC 2022 conversion factors for the most commonly prescribed oral opioids plus the standard fentanyl transdermal conversion (mcg/hr × 2.4 = MME/day). Methadone is dose-tiered per the CDC 2022 guideline because of its non-linear potency profile.
This tool is for educational and decision-support use only. It does not replace independent clinical judgement. Always verify against the current guideline, FDA label, or specialty reference cited below before acting. Do not enter patient identifiers (name, MRN, dates of service).
Tool
Who this is for
- Primary care, palliative care, and pain medicine clinicians
- Hospitalists managing opioid stewardship
- Pharmacists performing prescribing safety reviews
How to interpret the result
| Score / band | Interpretation |
|---|---|
| < 50 MME/day | Below the CDC 2022 threshold for additional caution. |
| ≥ 50 MME/day | CDC 2022 recommends additional risk-benefit review. |
| ≥ 90 MME/day | CDC 2022 recommends careful justification and monitoring; avoid escalation when feasible. |