Intracranial aneurysm risk in coronary artery disease with systemic atherosclerosis
Direct data quantifying the incidence (new-onset risk) of intracranial or intraparenchymal aneurysms specifically in patients with coronary artery disease (CAD) are not available from the retrieved literature. [1]
Available evidence on atherosclerotic burden and aneurysm risk
A retrospective case-control study using abdominal imaging-derived atherosclerotic burden found that higher abdominal aortic calcification index (ACI) was associated with increased risk of ruptured intracranial aneurysm compared with matched controls without intracranial aneurysm. [1]
Quantified association with aneurysm rupture
For ruptured intracranial aneurysm, each increment in ACI increased odds by OR 1.02 (95% CI 1.01–1.03) versus matched controls. [1]
For ruptured intracranial aneurysm, ACI greater than 3 increased odds by OR 5.77 (95% CI 3.29–10.11) versus matched controls. [1]
Evidence regarding coexisting coronary artery disease
In the same study, a history of coronary artery disease was reported to be less frequent in ruptured intracranial aneurysm cases compared with matched controls. [1]
Data gap for “development” of aneurysms
No retrieved study provided an incidence rate or prospective estimate for developing intracranial or intraparenchymal aneurysms over time in a CAD population. [1]