Vitamin K (Phytonadione) Dosing for Pediatric Acute Hepatitis With Elevated INR
Vitamin K repletion is recommended in pediatric acute liver dysfunction with coagulopathy based on an age- and weight-appropriate dose range. [1]
Recommended Phytonadione Dose
- Infants: 1 mg vitamin K (phytonadione) [1]
- Older adolescents: up to 10 mg vitamin K (phytonadione) [1]
Route of Administration
- Oral vitamin K therapy should not be used to correct the INR in pediatric acute liver failure. [1]
- Subcutaneous administration should be used to ensure administration. [1]
INR-Guided Escalation
Dose and route should be reassessed based on response of coagulation indices. [1]