Olanzapine Starting Dose for Adults
For adults with schizophrenia, oral olanzapine is recommended to be started at 5–10 mg once daily, with a target of 10 mg/day within several days (Class I recommendation for indicated dosing in the U.S. prescribing information). [1]
For adults with bipolar I disorder (manic or mixed episodes), oral olanzapine is recommended to be started at 10 or 15 mg once daily. [2]
Lower Starting Dose in Sensitive or Debilitated Patients
In patients who are debilitated or who have a predisposition to hypotensive reactions or slower metabolism/pharmacodynamic sensitivity (examples include nonsmoking female patients ≥65 years of age), the recommended starting dose is 5 mg. [1][2]
Formulation Notes
These starting-dose recommendations apply to oral olanzapine dosing as described in the U.S. prescribing information for olanzapine tablets (and corresponding oral formulations). [1][2]