Uncomplicated Diverticulitis Antibiotic Dosing in Adults
Oral levofloxacin dosing for acute uncomplicated diverticulitis in adults is levofloxacin 500 mg by mouth every 24 hours for 4–7 days when used as part of a recommended antibiotic regimen [1].
Treatment Duration
The recommended course length is 4–7 days [1].
Drug Regimen Context
Levofloxacin 500 mg by mouth every 24 hours is listed as an option in combination therapy with metronidazole 500 mg by mouth every 8 hours for acute uncomplicated diverticulitis [1].
Patient Phenotype Criteria
Antibiotic therapy is recommended for acute uncomplicated diverticulitis in patients with high-risk features (eg, immunocompromise, frailty, medically complex status, inability to tolerate oral intake, worsening clinical course, markedly elevated inflammatory markers, or higher-risk imaging features, or lack of reliable follow-up/support) [1].