What is the maximum recommended dose of guanfacine (extended‑release) for an 8‑year‑old female with attention‑deficit/hyperactivity disorder, increased irritability and emotional outbursts, weighing approximately 110 lb (≈50 kg)?

Guanfacine Extended-Release Maximum Recommended Dose for Pediatric ADHD

The maximum recommended dose of guanfacine extended-release (GXR) for children aged 6 to 17 years with ADHD is 4 mg once daily. [1]

Maximum Dose Recommendation

• Maximum dose: 4 mg/day (once daily). [1]

Dose Titration Used in Pediatric Trials

• Starting dose: 2 mg/day. [1]
• Titration: 1-mg increments as needed. [1]
• Titration target: up to the maximum of 4 mg/day. [1]

Weight Considerations

• The maximum recommended dose is fixed by age range (6–17 years) in studied regimens and is not adjusted by body weight. [1]