Elimination half-life of oral semaglutide
Oral semaglutide (brand: Rybelsus) has an elimination half-life of approximately 1 week. [1]
Dose duration in circulation after last dose
Semaglutide is present in circulation for about 5 weeks after the last oral dose. [1]
Product clarification
Wegovy is a semaglutide product formulated for subcutaneous use rather than oral use. [2]
Key prescribing-information statement
The FDA prescribing information for oral semaglutide states: “Semaglutide elimination half-life is approximately one week.” [1]