Initial Ceftriaxone Dose for Uncomplicated Gonorrhea
CDC recommends ceftriaxone 500 mg intramuscularly (IM) as a single dose for uncomplicated urogenital, rectal, and pharyngeal gonorrhea in persons weighing <150 kg. [1] CDC recommends ceftriaxone 1 g IM as a single dose for uncomplicated gonorrhea in persons weighing ≥150 kg. [1]
Route and Dosing Structure
Ceftriaxone is given as a single IM injection. [1] The weight-based dose adjustment is based on a 150-kg threshold. [1]
Indication Scope
The above ceftriaxone dosing applies to uncomplicated urogenital, anorectal, and pharyngeal infection. [1]
Key Treatment Co-Management Nuance
If chlamydial infection has not been excluded, concurrent treatment for chlamydia should be provided with doxycycline 100 mg orally twice daily for 7 days. [1]
Common Error to Avoid
Administering ceftriaxone 500 mg IM once in persons weighing ≥150 kg without dose escalation is inconsistent with CDC dosing. [1]