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What are the indications for oral progesterone?

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Last updated: July 14, 2026 · View editorial policy

Indications for Oral Progesterone

Oral progesterone is indicated for specific postmenopausal hormone therapy and menstrual cycle indications depending on the exact FDA-labeled product formulation. [1]

Prevention of Endometrial Hyperplasia During Estrogen Therapy

Oral progesterone capsules are indicated to prevent endometrial hyperplasia in a postmenopausal woman with a uterus who is receiving daily conjugated estrogens. [1]

Treatment of Secondary Amenorrhea

Oral progesterone capsules are indicated for the treatment of secondary amenorrhea due to a decrease in progesterone when endogenous progesterone production is insufficient. [1]

Treatment of Moderate to Severe Vasomotor Symptoms Due to Menopause (Oral Estradiol + Progesterone)

The oral combination product estradiol and progesterone (BIJUVA) is indicated in a woman with a uterus for the treatment of moderate to severe vasomotor symptoms due to menopause. [2]

Product-Dependent Indication Scope

Oral progesterone capsules have labeling focused on endometrial protection during conjugated estrogens therapy and menstrual irregularity due to progesterone deficiency. [1]

Practical Formulation Matching for Labeled Use

  • Oral progesterone capsules (progesterone alone) are used for endometrial hyperplasia prevention with conjugated estrogens or for secondary amenorrhea. [1]
  • Oral estradiol/progesterone (BIJUVA) is used for vasomotor symptom treatment in menopausal women with a uterus. [2]

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