Nicorandil intravenous infusion calculation (70-kg adult)
Nicorandil can be administered as an IV bolus of 0.2 mg/kg over 5 minutes, followed by a continuous infusion of 0.05–0.20 mg/kg/hour. [1]
Dosing for a 70-kg adult
- Loading (IV bolus): 0.2 mg/kg → 0.2 × 70 = 14 mg given over 5 minutes. [1]
- Maintenance infusion starting dose: 0.05 mg/kg/hour → 0.05 × 70 = 3.5 mg/hour. [1]
- Maintenance infusion range: 0.20 mg/kg/hour max → 0.20 × 70 = 14 mg/hour. [1]
Infusion pump rate conversion (requires final solution concentration)
Let C = nicorandil concentration in the prepared infusion bag (mg/mL).
- Pump rate (mL/hour) = (desired dose in mg/hour) ÷ C.
- Starting infusion pump rate: (3.5 mg/hour) ÷ C mL/hour. [1]
- Max range infusion pump rate: (14 mg/hour) ÷ C mL/hour. [1]
Practical preparation workflow (concentration-agnostic)
- Draw up the loading dose total of 14 mg for the 5-minute IV bolus. [1]
- Prepare the continuous infusion solution to an appropriate concentration C (mg/mL) using institution-approved diluent and compounding practices. (No specific concentration or diluent volumes were provided in the cited dosing sources.)
- Start the infusion at 3.5 mg/hour after the bolus and titrate within 3.5–14 mg/hour using the pump rate calculation above. [1]
Infusion rate expressed in mg/min (optional)
- 3.5 mg/hour = 0.0583 mg/min. [1]
- 14 mg/hour = 0.233 mg/min. [1]
Key referenced dosing regimen
Nicorandil regimens of 0.2 mg/kg over 5 minutes followed by 0.05, 0.10, or 0.20 mg/kg/hour continuous infusion have been used in clinical evaluation of hemodynamic effects in hospitalized patients. [1]
Pharmacokinetic infusion rates used in studies
Continuous infusion rates of 0.05–0.20 microgram/kg/min (healthy volunteer pharmacokinetic study) demonstrate concentration-time attainment at steady state over several hours. [2]