Buspirone Dose Adjustment and Tablet Splitting
Buspirone tablets can be divided to deliver 2.5 mg doses. [1]
2.5 mg Feasibility
Buspirone hydrochloride tablets labeled as 5 mg are scored so they can be bisected. [1]
Because of tablet scoring, a 5 mg tablet can provide a 2.5 mg dose. [1]
Usual Starting Dose
The recommended initial dose is 15 mg daily (7.5 mg twice daily). [2]
Use of 2.5 mg in Drug-Interaction Situations
When buspirone is coadministered with certain CYP3A4 inhibitors, low-dose buspirone has been specifically recommended, including examples such as 2.5 mg twice daily. [1]
Clinical Practical Considerations
Buspirone dose changes should follow the prescriber’s titration plan. [2]
Buspirone bioavailability is affected by food, so dosing should be kept consistent with regard to timing either always with food or always without food. [2]