At what serum triglyceride concentration should the propofol infusion be stopped? | Rounds At what serum triglyceride concentration should the propofol infusion be stopped? | Rounds

At what serum triglyceride concentration should the propofol infusion be stopped?

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Discontinuation Threshold for Propofol Infusion Based on Serum Triglycerides

Propofol infusion should be discontinued when serum triglycerides exceed 250 mg/dL. [1]

When a Fixed Triglyceride Cutoff Is Not Universally Specified

The propofol prescribing information recommends immediate discontinuation when signs of propofol infusion syndrome (PRIS) develop, but it does not provide a single triglyceride concentration cutoff to trigger discontinuation. [2]

Sources (2)

[1] Guideline 2017
UNC PICU Propofol Continuous Infusion Guideline for use dur…
University of North Carolina (UNC) Pediatric Critical Care Medicine
View Source
[2] Guideline 2022
PROPOFOL- propofol injection, emulsion (Prescribing Informa…
DailyMed (FDA Prescribing Information)
View Source

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